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Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study

2019; Elsevier BV; Volume: 19; Issue: 7 Linguagem: Inglês

10.1016/s1473-3099(19)30297-x

1474-4457

Stephanie W. Lo, Rebecca A. Gladstone, Andries J. van Tonder, John A. Lees, Mignon du Plessis, Rachel Benisty, Noga Givon‐Lavi, Paulina A. Hawkins, Jennifer Cornick, Brenda Kwambana-Adams, Pierra Y. Law, Pak‐Leung Ho, Martín Antonio, Dean Everett, Ron Dagan, Anne von Gottberg, Keith P. Klugman, Lesley McGee, Robert F. Breiman, Stephen D. Bentley, Abdullah Brooks, Alejandra Corso, Alexander Davydov, Alison J. Maguire, Andrew J. Pollard, Anmol Kiran, Anna Skoczyńska, Benild Moiane, Bernard Beall, Betuel Sigaúque, David M. Aanensen, Deborah Lehmann, Diego Faccone, Ebenezer Foster-Nyarko, Ebrima Bojang, Egorova Ea, Е. А. Воропаева, Eric Sampane-Donkor, Ewa Sadowy, Godfrey Bigogo, Hélio Mucavele, Houria Belabbès, Idrissa Diawara, Jennifer C. Moïsi, Jennifer R. Verani, Jeremy D. Keenan, Jyothish Bhai, Kedibone Ndlangisa, Khalid Zerouali, K L Ravikumar, Leonid Titov, Linda de Gouveia, Maaike Alaerts, Margaret Ip, Maria Cristina de Cunto Brandileone, Md Hasanuzzaman, Metka Paragi, Michele Nurse-Lucas, Mushal Ali, Naima Elmdaghri, Nicholas J. Croucher, Nicole Wolter, Nurit Porat, Özgen Köseoğlu Eser, Patrick Eberechi Akpaka, Paul Turner, Paula Gagetti, Peggy-Estelle Tientcheu, Philip E. Carter, Rafal Mostowy, Rama Kandasamy, Rebecca Ford, Rebecca Henderson, Roly Malaker, Sadia Shakoor, Samanta Cristine Grassi Almeida, Samir K. Saha, Sanjay Doiphode, Shabir A. Madhi, Shamala Devi Sekaran, Somporn Srifuengfung, Stephen Obaro, Stuart C. Clarke, Susan Nzenze, Tamara Kastrin, Theresa J. Ochoa, Balaji Veeraraghavan, Waleria Hryniewicz, Yulia Urban,

Pneumocystis jirovecii pneumonia detection and treatment

Invasive pneumococcal disease remains an important health priority owing to increasing disease incidence caused by pneumococci expressing non-vaccine serotypes. We previously defined 621 Global Pneumococcal Sequence Clusters (GPSCs) by analysing 20 027 pneumococcal isolates collected worldwide and from previously published genomic data. In this study, we aimed to investigate the pneumococcal lineages behind the predominant serotypes, the mechanism of serotype replacement in disease, as well as the major pneumococcal lineages contributing to invasive pneumococcal disease in the post-vaccine era and their antibiotic resistant traits.