Cleavage of the oxygen bridge in 8-oxabicyclo[3.2.1]octanes by reductive elimination
2001; Elsevier BV; Volume: 57; Issue: 51 Linguagem: Inglês
10.1016/s0040-4020(01)01051-1
ISSN1464-5416
AutoresBaldur Föhlisch, Günter Kreiselmeier,
Tópico(s)Cancer Treatment and Pharmacology
ResumoAbstract Several 2(4)-bromo- or chloro-8-oxabicyclo[3.2.1]oct-6-en-3-ones (2), available by [4+3] cycloaddition of monohalogeno-oxyallyl intermediates with furans, were reduced to halogenated 8-oxabicyclo[3.2.1]oct-6-en-3endo-ols (6) and saturated analogues (7). Cycloheptene-1,3trans-diols (8,11) were formed preferentially by reductive elimination.
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