A versatile synthesis of fused triazolo derivatives by sequential Ugi/alkyne-azide cycloaddition reactions
2004; Elsevier BV; Volume: 45; Issue: 46 Linguagem: Inglês
10.1016/j.tetlet.2004.09.117
ISSN1873-3581
AutoresIrini Akritopoulou‐Zanze, Vijaya Gracias, Stevan W. Djurić,
Tópico(s)Synthesis and Biological Evaluation
ResumoWe report a facile synthesis of fused dihydrotriazolo[1,5-a]pyrazinones and triazolobenzodiazepines by an Ugi/alkyne–azide cycloaddition synthetic sequence. The coupling of the Ugi multi-component reaction with the intramolecular alkyne–azide cycloaddition provides access to highly functionalized heterocyclic ring systems in two steps from easily available starting materials in excellent overall yields.
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