Reaction of Terminal Alkynes with Hydrazines To Give Nitriles, Catalyzed by TpRuCl(PPh 3 ) 2 : Novel Catalytic Transformation Involving a Vinylidene Ruthenium Intermediate
2002; American Chemical Society; Volume: 21; Issue: 19 Linguagem: Inglês
10.1021/om020588d
ISSN1520-6041
AutoresYoshiya Fukumoto, Toshifumi Dohi, Hideo Masaoka, Naoto Chatani, Shinji Murai,
Tópico(s)Catalytic Cross-Coupling Reactions
ResumoThe reaction of terminal alkynes with hydrazines in the presence of TpRuCl(PPh3)2 (Tp = tris(pyrazolyl)borate) as a catalyst gave nitriles. This reaction involves the intermolecular attack of nitrogen nucleophiles at the α-carbon atom of (vinylidene)metal intermediates which are generated from terminal alkynes.
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