A short, efficient synthesis of the chiral auxiliary (+)-8-phenylneomenthol
2000; Elsevier BV; Volume: 41; Issue: 21 Linguagem: Inglês
10.1016/s0040-4039(00)00594-3
ISSN1873-3581
AutoresOlga Caamaño, Franco Fernández, Xerardo García‐Mera, José E. Rodríguez‐Borges,
Tópico(s)Synthetic Organic Chemistry Methods
Resumo(+)-8-Phenylneomenthol 2, the structure of which was confirmed by X-ray analysis of its 3,5-dinitrobenzoate, was efficiently prepared from commercially available (−)-8-phenylmenthol 3 by oxidation with the Sarett reagent, followed by L-Selectride reduction of the (+)-8-phenylmenthone 6 thus formed.
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