A New Preparation of Optically Active N -Acyloxazolidinones via Ruthenium-Catalyzed Enantioselective Hydrogenation
1998; American Chemical Society; Volume: 63; Issue: 6 Linguagem: Inglês
10.1021/jo971733d
ISSN1520-6904
AutoresPierre Le Gendre, Patrice Thominot, Christian Bruneau, Pierre H. Dixneuf,
Tópico(s)Chemical Synthesis and Analysis
Resumoα-Methylene-N-acyloxazolidinones are readily prepared in three steps from propargylic alcohols via cyclic carbonates, and the enantioselective hydrogenation of the latter catalyzed by chiral (diphosphine)ruthenium complexes makes possible the obtention of both enantiomers of optically active N-acyloxazolidinones with very high enantioselectivities.
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