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Continuous flow whole cell bioreduction of fluorinated acetophenone

2014; Elsevier BV; Volume: 70; Issue: 20 Linguagem: Inglês

10.1016/j.tet.2013.12.036

1464-5416

Raquel de Oliveira Lopes, Joyce Benzaquem Ribeiro, Amanda Silva de Miranda, Gabriela Veloso Vieira da Silva, Leandro S. M. Miranda, Ivana Corrêa Ramos Leal, Rodrigo O. M. A. de Souza,

3D Printing in Biomedical Research

Several microorganism strains were used to reduce 2,2,2-trifluoroacetophenone (1) and 4′-Br-2,2,2-trifluoroacetophenone (3). Immobilized cells of Geotrichum candidum in calcium alginate led to conversion and enantiomeric excess higher than 99%. By using immobilized G. candidum cells under continuous flow conditions, the same conversion and enantiomeric excess were achieved in 90 min of residence time.