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Use of the Sharpless Asymmetric Dihydroxylation as a Substitute for the Katsuki-Sharpless Asymmetric Epoxidation: An Alternative Route to Vitamin E and Prostaglandin Intermediates

1994; Thieme Medical Publishers (Germany); Volume: 1994; Issue: 02 Linguagem: Inglês

10.1055/s-1994-22761

1437-2096

Seiichi Takano, Takehiko Yoshimitsu, Kunio Ogasawara,

Eicosanoids and Hypertension Pharmacology

It has been demonstrated that the Sharpless asymmetric dihydroxylation (AD) can be served as a substitute for the Katsuki-Sharpless asymmetric epoxidation (AE) in the synthesis of vitamin E and prostaglandin intermediates by using terminal chloromethylalkenyl substrates.