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ChemInform Abstract: Highly Enantioselective Organocatalytic Cascade Reaction for the Synthesis of Piperidines and Oxazolidines.

2012; Wiley; Volume: 43; Issue: 13 Linguagem: Inglês

10.1002/chin.201213164

1431-5890

Sylva Číhalová, Guillem Valero, Jiří Schimer, Marek Humpl, Martin Dračínský, Albert Moyano, Ramón Rios, Ján Veselý,

Asymmetric Hydrogenation and Catalysis

Abstract Organocatalyzed Michael addition of amidomalonates, e.g. (I) and (VI), towards enals (II) followed by intramolecular hemiaminal formation provides enantioenriched piperidine derivatives (III) and (VII), resp., in up to 99% optical purity.