Tandem Zirconocene Homologation−Aldimine Allylation
2001; American Chemical Society; Volume: 3; Issue: 17 Linguagem: Inglês
10.1021/ol0163880
ISSN1523-7060
AutoresPeter Wipf, Christopher Kendall,
Tópico(s)Advanced Synthetic Organic Chemistry
ResumoHydrozirconation of internal and terminal alkynes followed by in situ transmetalation to dimethylzinc and treatment with diiodomethane leads to chain extended allylic organometallics. Addition to N-phosphinoyl or N-sulfonyl aldimines provides homoallylic amines in 48−87% yield and 3:2 to >20:1 diastereomeric ratios favoring anti-products.
Referência(s)