A versatile synthesis of polysubstituted pyrroles
2001; Elsevier BV; Volume: 42; Issue: 35 Linguagem: Inglês
10.1016/s0040-4039(01)01203-5
ISSN1873-3581
AutoresBharat Lagu, Meng Pan, Michael P. Wachter,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoThe aldol products formed by the reaction between α-(N-benzyl or N-Cbz)amino aldehydes and lithium enolates of various ketones, were subjected to hydrogenolysis to give polysubstituted pyrroles in good yields (50–91%). The scope and limitations of this methodology are explored.
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