Highly Active in Situ Catalysts for Anti-Markovnikov Hydration of Terminal Alkynes
2006; American Chemical Society; Volume: 8; Issue: 25 Linguagem: Inglês
10.1021/ol062455k
ISSN1523-7060
AutoresAurélie Labonne, Thomas Kribber, Lukas Hintermann,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoThe anti-Markovnikov hydration of terminal alkynes to give aldehydes is catalyzed by complexes derived in situ from air-stable [CpRu(η6-naphthalene)]PF6 (C) and 6-aryl-2-diphenylphosphinopyridines (L). Ligands L are readily available from a modular synthesis. Increasing the size of the ligand C-6 aryl group in the order R = Ph < mesityl < 2,4,6-triisopropylphenyl < (2,4,6-triphenyl)phenyl gave hydration catalysts of highest known activity.
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