An investigation into the alkylation of 1,2,4-triazole
2000; Elsevier BV; Volume: 41; Issue: 8 Linguagem: Inglês
10.1016/s0040-4039(99)02272-8
ISSN1873-3581
AutoresPaul G. Bulger, Ian F. Cottrell, Cameron J. Cowden, Antony J. Davies, Ulf‐H. Dolling,
Tópico(s)Chemical Synthesis and Analysis
ResumoThe alkylation of 1,2,4-triazole with 4-nitrobenzyl halides and a variety of bases afforded the 1- and 4-alkylated isomers with a consistent regioselectivity of 90:10. Previously reported regiospecific alkylations of 1,2,4-triazole were re-examined and the quoted isomer ratios were shown to depend on the isolation procedure. The use of DBU as base in the alkylation of 1,2,4-triazole allows for a convenient and high yielding synthesis of 1-substituted-1,2,4-triazoles.
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