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Gold Nanoparticles Regulate Tight Junctions and Improve Cetuximab Effect in Colon Cancer Cells

2019; Future Medicine; Volume: 14; Issue: 12 Linguagem: Inglês

10.2217/nnm-2019-0023

1748-6963

Fernanda Leve, Daniella Paiva Bonfim, Giselle N. Fontes, José Andrés Morgado‐Díaz,

MicroRNA in disease regulation

Aim: Colon cancer (CC) is the second cause of cancer death worldwide. The use of nanoparticles for drug delivery has been increasing in cancer clinical trials over recent years. Materials & methods: We evaluated cytotoxicity of citrate-capped gold nanoparticles (GNPs) and the role they play on cell–cell adhesion. We also used GNP for delivery of cetuximab into different CC cell lines. Results: CC cells with well-formed tight junctions impair GNP uptake. Noncytotoxic concentration of GNP increases paracellular permeability in Caco-2 cells in a reversible way, concomitantly to tight junctions proteins CLDN1 and ZO-1 redistribution. GNP functionalized with cetuximab increases death of invasive HCT-116 CC cells. Conclusion: GNP can be used for drug delivery and can improve efficiency of CC therapy.