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Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

2019; Elsevier BV; Volume: 71; Issue: 3 Linguagem: Inglês

10.1016/j.jhep.2019.05.032

1600-0641

H. Wilman, Constantinos A. Parisinos, Naeimeh Atabaki‐Pasdar, Matt Kelly, E. Louise Thomas, Stefan Neubauer, Anubha Mahajan, Aroon D. Hingorani, Riyaz Patel, Harry Hemingway, Paul W. Franks, Jimmy D. Bell, Rajarshi Banerjee, Hanieh Yaghootkar, Christopher Jennison, Beate Ehrhardt, Patrick Baum, Corinna Schoelsch, Jan Freijer, Rolf Grempler, Ulrike Graefe‐Mody, Anita M. Hennige, Christiane Dings, Thorsten Lehr, Nina Scherer, Iryna Sihinecich, François Pattou, Violeta Raverdi, Robert Caïazzo, F. Torres, Hélène Verkindt, Andrea Mari, Andrea Tura, Toni Giorgino, Roberto Bizzotto, Philippe Froguel, Amelie Bonneford, Mickaël Canouil, Véronique Dhennin, Caroline Brorsson, Søren Brunak, Federico De Masi, Valborg Guðmundsdóttir, Helle K. Pedersen, Karina Banasik, Cecilia Engel Thomas, Peter Wad Sackett, Hans‐Henrik Stærfeldt, Agnete Troen Lundgaard, Birgitte Nilsson, Agnes Nielsen, Gianluca Mazzoni, Tugce Karaderi, Simon Rasmussen, Joachim Johansen, Rosa Lundbye Allesøe, Andreas Fritsche, Barbara Thorand, Jerzy Adamski, Harald Grallert, Mark Haid, Sapna Sharma, Martina Troll, Jonathan Adam, Jorge Ferrer, Heather Eriksen, Gary Frost, Ragna S. Häussler, Mun‐Gwan Hong, Jochen M. Schwenk, Mathias Uhlén, Claudia Nicolay, Imre Pávó, Birgit Steckel-Hamann, Melissa K. Thomas, Kofi Adragni, Han Wu, Leen't Hart, Slieker Roderick, Nienke van Leeuwen, Koen F. Dekkers, Francesca Frau, Johann Gassenhuber, Bernd Jablonka, Petra Musholt, Hartmut Ruetten, J. Tillner, Tania Baltauss, Oana Bernard Poenaru, Nathalie de Préville, Marianne Rodriquez, Manimozhiyan Arumugam, Kristine H. Allin, Line Engelbrechtsen, Torben Hansen, Tue H. Hansen, Annemette Forman, Anna Jonsson, Oluf Pedersen, Avirup Dutta, Josef Korbinian Vogt, Henrik Vestergaard, Markku Laakso, Tarja Kokkola, Teemu Kuulasmaa, Paul W. Franks, Nick N. Giordano, Hugo Pomares‐Millan, Hugo Fitipaldi, Pascal M. Mutie, Maria Klintenberg, Margit Bergstrom, Per‐Henrik Groop, Martin Ridderstråle, Naeimeh Atabaki Pasdar, Harshal Deshmukh, Alison Heggie, Dianne Wake, Donna McEvoy, Ian McVittie, Mark Walker, Andrew T. Hattersley, Anita Hill, Angus G. Jones, Timothy J. McDonald, Mandy H. Perry, Rachel Nice, Michelle Hudson, Claire E. Thorne, Emmanouil T. Dermitzakis, Ana Viñuela, Louise Cabrelli, Heather Loftus, Adem Y. Dawed, Louise A. Donnelly, Ian Forgie, Ewan R. Pearson, Nicholette D. Palmer, Andrew Brown, Robert W. Koivula, Agata Wesolowska‐Andersen, Moustafa Abdalla, Nicky McRobert, Juan Fernandez, Yunlong Jiao, Neil Robertson, Stephen Gough, Jane Kaye, Miranda Mourby, Anubha Mahajan, Mark I. McCarthy, Nisha Shah, Harriet Teare, Reinhard W. Holl, Anitra D.M. Koopman, Femke Rutters, Joline W. J. Beulens, Lenka Groeneveld, Anitra D.M. Koopman, Jimmy D. Bell, E. Louise Thomas, Brandon Whitcher,

Folate and B Vitamins Research

Excess liver iron content is common and is linked to the risk of hepatic and extrahepatic diseases. We aimed to identify genetic variants influencing liver iron content and use genetics to understand its link to other traits and diseases.