Asymmetric synthesis of functionalized benzo[a]quinolizine derivatives via a diastereoselective N-acyliminium ion cyclization
1997; Elsevier BV; Volume: 53; Issue: 9 Linguagem: Inglês
10.1016/s0040-4020(97)00070-7
ISSN1464-5416
AutoresYong Sup Lee, Soosung Kang, Jung Hoon Choi, Hokoon Park,
Tópico(s)Alkaloids: synthesis and pharmacology
ResumoAbstract A chiral synthesis of functionalized benzo[a]quinolizine derivative (5) has been accomplished starting from a chiral lactone 7. The key feature is the efficient control of the stereochemistry of ring juncture of the functionalized benzo[a]quinolizine derivative 5 by the N-acyliminium ion cyclization of chiral lactam 11b.
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