Regioselective Control of Electrophilic Aromatic Substitution Reactions
2004; Bentham Science Publishers; Volume: 1; Issue: 3 Linguagem: Inglês
10.2174/1570179043366747
ISSN1875-6271
AutoresKeith Smith, Gamal A. El‐Hiti,
Tópico(s)Asymmetric Synthesis and Catalysis
Resumopara-Regioselective electrophilic aromatic substitution reactions, for example nitration, alkylation, acylation, sulfonylation and halogenation, can be achieved by carrying out reactions over solid catalysts such as zeolites, under modest conditions via shape-selectivity. By contrast, organolithium reagents can play an important role when ortho-products are desirable. ortho-Lithiation has been applied for the synthesis of more complex substituted heterocycles that are difficult to prepare by other means.
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