Steric effects in high pressure Knoevenagel reactions
2001; Elsevier BV; Volume: 42; Issue: 2 Linguagem: Inglês
10.1016/s0040-4039(00)01930-4
ISSN1873-3581
Autores Tópico(s)Multicomponent Synthesis of Heterocycles
ResumoThe pressure effect in Knoevenagel condensations involving ketones and ethyl cyanoacetate is studied. The reactions are diversely affected. For cyclic ketones there is a small effect on the reaction yield. However, in the case of acyclic ketones, the sensitivity of the reaction to pressure increases with increasing steric congestion of the ketone. Such a result highlights the synthetic utility of high pressure for the preparation of hindered functionalized alkenes.
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