An efficient α-hydroxylation of carbonyls using the HOF•CH3CN complex
1999; Elsevier BV; Volume: 55; Issue: 12 Linguagem: Inglês
10.1016/s0040-4020(98)01173-9
ISSN1464-5416
AutoresSharon Dayan, Yífat Bareket, Shlomo Rozen,
Tópico(s)Chemical Synthesis and Reactions
ResumoThe complex HOF•CH3CN, made directly from fluorine and aqueous acetonitrile, was used for α-hydroxylation of various ketones, esters and acids via their trimethyl silyl enol ethers. The reaction is usually complete in a few minutes at room temperature or below and has high yields.
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