Improved Preparation of Enantiomerically Pure 5-Oxo Amino Acid Derivatives by Palladium-Catalysed Coupling Reactions
1995; Thieme Medical Publishers (Germany); Volume: 1995; Issue: 08 Linguagem: Inglês
10.1055/s-1995-5092
ISSN1437-2096
AutoresJoanne L. Fraser, Richard F. W. Jackson, Barry Porter,
Tópico(s)Chemical Synthesis and Analysis
ResumoThe organozinc reagent 3 reacts with unfunctionalised acid chlorides under palladium catalysis to give enantiomerically pure protected 5-oxo amino acids in good to excellent yields, provided dimethoxyethane (DME) is used as solvent. For functionalised acid chlorides, the solvent systems benzene/dimethylacetamide (DMA) or toluene/DMA are preferred.
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