Diastereoselective Baylis−Hillman Reactions: The Design and Synthesis of a Novel Camphor-Based Chiral Auxiliary
2000; American Chemical Society; Volume: 2; Issue: 6 Linguagem: Inglês
10.1021/ol990315n
ISSN1523-7060
Autores Tópico(s)Synthetic Organic Chemistry Methods
ResumoReaction of chiral acryloylhydrazide 5 derived from novel auxiliary 4 with aldehydes in the presence of DABCO affords practical levels (up to 98% de) of beta-hydroxy-alpha-methylene carbonyl derivatives, and high optical purity of both diastereomers of 6a-d and 7a-d can be obtained by changing the solvent.
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