Facile radical decarboxylative alkylation of heteroaromatic bases using carboxylic acids and trivalent iodine compounds
1991; Elsevier BV; Volume: 32; Issue: 45 Linguagem: Inglês
10.1016/0040-4039(91)80221-q
ISSN1873-3581
AutoresHideo Togo, Masahiko Aoki, Masataka Yokoyama,
Tópico(s)Fluorine in Organic Chemistry
ResumoMany kinds of heteroaromatic bases were easily alkylated by the reaction of carboxylic acids with [bis(trifluoroacetoxy)iodo]benzene or [bis(trifluoroacetoxy)iodo]pentafluorobenzene via radical decarboxylative pathways. This system was further applied to the reaction with tetrahydrofurylcarboxylic acid, 1-(2,3,5-tri-O-benyl)-D-ribofuranosylacetic acid, and 1-(2,3,5-tri-O-benzyl)-D-ribofuranosylcarboxylic acid for the model synthesis of C-nucleosides.
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