Portal de Periódicos da CAPES

Synthesis of 7‐ethyl‐4,7‐dihydro‐4‐oxo‐2‐(4‐pyridinyl)thieno[2,3‐ b ]pyridine‐5‐carboxylic acid

1991; Wiley; Volume: 28; Issue: 8 Linguagem: Inglês

10.1002/jhet.5570280826

1943-5193

Edward R. Bacon, Sol J. Daum,

Phenothiazines and Benzothiazines Synthesis and Activities

Abstract 7‐Ethyl‐4,7‐dihydro‐4‐oxo‐2‐(4‐pyridinyl)thieno[2,3‐ b ]pyridine‐5‐carboxylic acid ( 4 ), an analog of nalidixic acid, was synthesized in seven steps starting from commercially available 4‐methylpyridine. Bacterial susceptibility to compound 4 was tested and the title compound was found to exhibit only weak antibacterial activity against a variety of pathogens including S. Aureus, E. Coli and P. Aeruginosa .