Pictet–Spengler Reaction of Nitrones and Imines Catalyzed by Yb(OTf) 3 –TMSCl
2002; Oxford University Press; Volume: 31; Issue: 4 Linguagem: Inglês
10.1246/cl.2002.428
ISSN1348-0715
AutoresRiichiro Tsuji, Masamichi Yamanaka, Atsushi Nishida, Masako Nakagawa,
Tópico(s)Synthesis and pharmacology of benzodiazepine derivatives
ResumoAbstract The Pictet–Spengler reaction of nitrones and imines prepared from N-hydroxytryptamine and tryptamine gave the corresponding tetrahydro-β-carbolines in excellent yields in the presence of Yb(OTf)3–TMSCl in a mixture of CH2Cl2 and THF.
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