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Drug repurposing: a promising tool to accelerate the drug discovery process

2019; Elsevier BV; Volume: 24; Issue: 10 Linguagem: Inglês

10.1016/j.drudis.2019.06.014

1878-5832

Vineela Parvathaneni, Nishant S. Kulkarni, Aaron Muth, Vivek Gupta,

Pharmaceutical studies and practices

Traditional drug discovery and development involves several stages for the discovery of a new drug and to obtain marketing approval. It is necessary to discover new strategies for reducing the drug discovery time frame. Today, drug repurposing has gained importance in identifying new therapeutic uses for already-available drugs. Typically, repurposing can be achieved serendipitously (unintentional fortunate observations) or through systematic approaches. Numerous strategies to discover new indications for FDA-approved drugs are discussed in this article. Drug repurposing has therefore become a productive approach for drug discovery because it provides a novel way to explore old drugs for new use but encounters several challenges. Some examples of different approaches are reviewed here.