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Synthesis of via a tandem sharpless asymmetric dihydroxylation/lipase-catalyzed transesterification

1995; Elsevier BV; Volume: 36; Issue: 24 Linguagem: Inglês

10.1016/0040-4039(95)00778-b

1873-3581

Aditya Sobti, Gary A. Sulikowski,

Enzyme Catalysis and Immobilization

An enantioselective synthesis of the trideoxy sugar 4-O-acetyl-l-rhodinopyranose (7) is described. A key feature of the synthetic strategy is a Sharpless asymmetric dihydroxylation followed by a lipase-mediated mono-esterification of the resultant diol (3→4→6).