Synthesis of cyclic peptides as mimics for the constrained conformation of structural analogues of HIV protease inhibitors
2001; Elsevier BV; Volume: 42; Issue: 2 Linguagem: Inglês
10.1016/s0040-4039(00)01951-1
ISSN1873-3581
AutoresErode N. Prabhakaran, V. Rajesh, Shalini Dubey, Javed Iqbal,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoA γ-turn induced cyclisation of tripeptides 4 can be performed in a ring-closing metathesis reaction using Grubb's catalyst to the corresponding cyclic peptides 5. These cyclic peptides mimic the constrained conformation of structural analogues of potential HIV protease inhibitors.
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