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Treatment and survival of locally recurrent rectal cancer: A cross-sectional population study 15 years after the Dutch TME trial

2019; Elsevier BV; Volume: 45; Issue: 11 Linguagem: Inglês

10.1016/j.ejso.2019.06.016

1532-2157

Robin Detering, Eleonora G. Karthaus, Wernard A. A. Borstlap, Corrie A.M. Marijnen, Cornelis J.�H. van de Velde, Willem A. Bemelman, Geerard L. Beets, Pieter J. Tanis, Arend G. J. Aalbers, Arend G. J. Aalbers, Yaïr I. Z. Acherman, G. D. Algie, B. Alting von Geusau, Folker Amelung, T.S. Aukema, Ilsalien S. Bakker, Stephan Bartels, Shaik Mahaboob Basha, A.J.N.M. Bastiaansen, Eric H.J. Belgers, Wim Bleeker, Joost M. Blok, R.J.I. Bosker, Joanna W. A. M. Bosmans, M. C. Boute, Nicole D. Bouvy, H. Bouwman, Alexandra R. M. Brandt‐Kerkhof, David J. Brinkman, S. Bruin, Emma R.J. Bruns, J.P.M. Burbach, Jacobus W. A. Burger, Christianne J. Buskens, S. H. E. M. Clermonts, P. P. L. O. Coene, C. Compaan, E.C.J. Consten, T. Darbyshire, Sylvana M.L. de Mik, Eelco J. R. de Graaf, Imelda J. M. de Groot, R de Vos tot Nederveen Cappel, Johannes H. W. de Wilt, James van der Wolde, FC den Boer, Jan Willem T. Dekker, A. Demirkiran, M. Derkx-Hendriksen, Feike Dijkstra, Peter van Duijvendijk, M. S. Dunker, Q. E. Eijsbouts, Hans F. J. Fabry, F. Ferenschild, J. W. Foppen, Edgar J.B. Furnée, Michael F. Gerhards, P. van Gerven, J. A. H. Gooszen, Johannes A. Govaert, Wilhelmina M. U. van Grevenstein, R. Haen, Joris J. Harlaar, Erwin van der Harst, Klaas Havenga, Jeroen Heemskerk, Jos Heeren, B. Heijnen, P. Heres, Christiaan Hoff, Wouter Hogendoorn, Piet V. Hoogland, A. Huijbers, Patricia A. Janssen, Audrey C. H. M. Jongen, F.H.W. Jonker, Eleonora G. Karthaus, A. Keijzer, J. M. A. Ketel, J. Klaase, F.W.H. Kloppenberg, M.E. Kool, R.T.J. Kortekaas, P Kruyt, Jan-Willem Kuiper, Bas Lamme, Johan F. Lange, T. Lettinga, Daniel J. Lips, F. Logeman, Martijn F. Lutke Holzik, Eva V. E. Madsen, Aziz Mamound, C. C. M. Marres, Ilse Masselink, M. Meerdink, Anand G. Menon, J. Sven D. Mieog, D. Mierlo, G.D. Musters, Grard A. P. Nieuwenhuijzen, Peter A. Neijenhuis, Joost Nonner, M. Oostdijk, Steven J. Oosterling, P. M. P. Paul, Koen Peeters, Ilona T. A. Pereboom, Fatih Polat, Pieter Poortman, Marco Raber, Beata M. M. Reiber, R J Renger, Charles C. van Rossem, Heidi Rütten, Annemarieke Rutten, R. Schaapman, M. Scheer, Lotte Schoonderwoerd, N. Schouten, Michiel F. Schreuder, Wilhelmina H. Schreurs, Geert A. Simkens, Gerrit D. Slooter, H. C. E. Sluijmer, Niels Smakman, Robert Jan Smeenk, H.S. Snijders, D J A Sonneveld, B. Spaansen, EJ Spillenaar Bilgen, E. Ph. Steller, Willem H. Steup, C. Steur, E. Stortelder, J. Straatman, Hilko A. Swank, Colin Sietses, H.A. Groen, HG ten Hoeve, WW ter Riele, I. M. Thorensen, B. Tip-Pluijm, Boudewijn R. Toorenvliet, Larissa Tseng, Jurriaan B. Tuynman, James van Bastelaar, S.C. van Beek, Anthony W. H. van de Ven, M.A.J. van de Weijer, C. van den Berg, I. van den Bosch, J D W van der Bilt, S. J. van der Hagen, R. van der Hul, George van der Schelling, Arco van der Spek, Nicole van der Wielen, Eino van Duyn, C. van Eekelen, Jeroen A. van Essen, K. van Gangelt, A. A. W. van Geloven, Chris van Kessel, Yu‐Ting van Loon, Anne-Sophie van Rijswijk, Stefanus J. van Rooijen, T. van Sprundel, L. van Steensel, Willem F. van Tets, Henderik L. van Westreenen, S. Veltkamp, T. Verhaak, Paul M. Verheijen, L. Versluis-Ossenwaarde, S. Vijfhuize, Wouter J. Vles, Stijn C. Voeten, F. Jeroen Vogelaar, W. W. Vrijland, E. Westerduin, Marinke Westerterp, Martha Wetzel, Kevin P. Wevers, B. Wiering, Caroline D.M. Witjes, Michel W.J.M. Wouters, Simon T.K. Yauw, Edwin S. van der Zaag, Eliane C.M. Zeestraten, D. D. E. Zimmerman, T. Zwieten,

Gastric Cancer Management and Outcomes

Introduction Optimized treatment of primary rectal cancer might have influenced treatment characteristics and outcome of locally recurrent rectal cancer (LRRC). Subgroup analysis of the Dutch TME trial showed that preoperative radiotherapy (PRT) for the primary tumour was an independent poor prognostic factor after diagnosis of LRRC. This cross-sectional population study aimed to evaluate treatment and overall survival (OS) of LRRC patients, stratified for prior preoperative radiotherapy (PRT) and intention of treatment of LRRC. Methods All patients developing LRRC were selected from a collaborative Snapshot study on 2095 surgically treated rectal cancer patients from 71 Dutch hospitals in the year 2011. Cox proportional hazard analysis was performed to determine predictors for OS. Results A total of 107 LRRC patients (5.1%) were included, of whom 88 (82%) underwent PRT for their primary tumour. LRRC was treated with initial curative intent in 31 patients (29%), with eventual resection in 20 patients (19%). Median OS was 22 and 8 months after curative and palliative intent treatment, respectively (p < 0.001). Initial CRM positivity and palliative intent treatment were associated with worse OS after LRRC, while prior PRT was not. Conclusions This cross-sectional study revealed that rectal cancer patients, who underwent curative resection in the Netherlands in 2011 and subsequently developed local recurrence, were amenable for again curative intent treatment in 29%, with a corresponding median survival of 22 months. Prior PRT was not significantly associated with survival after diagnosis of LRRC.