Stereoselective Michael addition of trimethyl aluminium to nitro acrylates: a route to 2-methyl-3-amino propionic acid
2003; Elsevier BV; Volume: 14; Issue: 20 Linguagem: Inglês
10.1016/s0957-4166(03)00575-5
ISSN1362-511X
AutoresUwe Eilitz, F. Leßmann, Oliver Seidelmann, Volkmar Wendisch,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoThe copper(I)-catalysed Michael addition of trimethyl aluminium to nitro acrylates yields 2-methyl-3-nitro propionic acid esters on a 200 g scale with enantiomeric excesses up to 92%.
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