Stereoselective synthesis of β-amino ketones via direct Mannich-type reaction catalyzed with silica sulfuric acid
2007; Elsevier BV; Volume: 63; Issue: 11 Linguagem: Inglês
10.1016/j.tet.2007.01.015
ISSN1464-5416
AutoresHui Wu, Yang Shen, Liyan Fan, Yu Wan, Pu Zhang, Caifa Chen, Wenxiang Wang,
Tópico(s)Chemical Synthesis and Reactions
ResumoAt room temperature, the direct Mannich-type reaction of a variety of in situ generated aldimines using aldehydes and anilines with ketones in a three-component reaction was efficiently catalyzed by silica sulfuric acid (SSA) in EtOH. This rapid reaction afforded the corresponding β-amino ketones in good yields with excellent stereoselectivities and catalyst was recyclable.
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