Pibocin, the first ergoline marine alkaloid from the Far-Eastern ascidian Eudistoma sp.
1999; Elsevier BV; Volume: 40; Issue: 8 Linguagem: Inglês
10.1016/s0040-4039(98)02652-5
ISSN1873-3581
AutoresTatyana N. Makarieva, S.G. Ilyin, Valentin A. Stonik, Konstantin А. Lyssenko, В. А. Денисенко,
Tópico(s)Chemical synthesis and alkaloids
ResumoPibocin1 (1), the first representative of marine ergoline alkaloids, was isolated from the Far-Eastern ascidian Eudistoma sp. Its structure and absolute stereochemistry have been established as (8β)-2-bromo-6,8-dimethylergoline on the basis of spectroscopic and X-Ray analysis data. Pibocin showed moderate cytotoxic activity against mouse Ehrlich carcinoma cells.
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