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Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp. II. Isolation, Characterization, and Structure Determination.

2003; Springer Nature; Volume: 56; Issue: 3 Linguagem: Inglês

10.7164/antibiotics.56.232

1881-1469

John E. Leet, Wenying Li, HELEN A. AX, James A. Matson, Stella Huang, Ron Huang, Joseph L. Cantone, Dieter M. Drexler, R. A. Dalterio, Kin S. Lam,

Actinomycetales infections and treatment

A new group of thiazolyl peptide antibiotics, the nocathiacins, was isolated from cultured broth of Nocardia sp. The major analogs nocathiacins I-III (1-3) were purified using silica gel and Sephadex LH-20 chromatography techniques. The structures of nocathiacins I-III were determined by spectroscopic (2D-NMR, MSn) methods, and share structural similarities to glycothiohexide-alpha (4).