Highly efficient ortho-fluoro-dimeric cinchona-derived phase-transfer catalysts
2003; Elsevier BV; Volume: 44; Issue: 17 Linguagem: Inglês
10.1016/s0040-4039(03)00687-7
ISSN1873-3581
AutoresHyeung‐geun Park, Byeong‐Seon Jeong, Mi‐Sook Yoo, Jeong Hee Lee, Boon‐saeng Park, Myoung Goo Kim, Sang‐sup Jew,
Tópico(s)Fluorine in Organic Chemistry
ResumoA series of cinchona alkaloid-derived dimeric quaternary ammonium salts were prepared as chiral phase-transfer catalysts by the introduction of various functional groups on the phenyl ligand. Among them, the 2-F-substituted derivative 21 showed the highest enantioselectivity in the alkylation of the glycine anion equivalent 1 (97 to >99% ee).
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