Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
2018; Nature Portfolio; Volume: 9; Issue: 1 Linguagem: Inglês
10.1038/s41467-018-07070-8
ISSN2041-1723
AutoresArthur Gilly, Dániel Süveges, Karoline Kuchenbaecker, Martin Pollard, Lorraine Southam, Konstantinos Hatzikotoulas, Aliki‐Eleni Farmaki, Thea Bjørnland, Ryan K. Waples, Emil V. R. Appel, Elisabetta Casalone, Giorgio Melloni, Britt Kilian, Nigel W. Rayner, Ιωάννα Ντάλλα, Kousik Kundu, Klaudia Walter, John Danesh, Adam S. Butterworth, Inês Barroso, Emmanouil Tsafantakis, George Dedoussis, Ida Moltke, Eleftheria Zeggini,
Tópico(s)Genomics and Rare Diseases
ResumoThe role of rare variants in complex traits remains uncharted. Here, we conduct deep whole genome sequencing of 1457 individuals from an isolated population, and test for rare variant burdens across six cardiometabolic traits. We identify a role for rare regulatory variation, which has hitherto been missed. We find evidence of rare variant burdens that are independent of established common variant signals (ADIPOQ and adiponectin, P = 4.2 × 10-8; APOC3 and triglyceride levels, P = 1.5 × 10-26), and identify replicating evidence for a burden associated with triglyceride levels in FAM189B (P = 2.2 × 10-8), indicating a role for this gene in lipid metabolism.
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