Nagelamides M and N, new bromopyrrole alkaloids from sponge Agelas species
2008; Elsevier BV; Volume: 64; Issue: 48 Linguagem: Inglês
10.1016/j.tet.2008.09.039
ISSN1464-5416
AutoresTakaaki Kubota, Atsushi Araki, Junji Ito, Yuzuru Mikami, Jane Fromont, Jun’ichi Kobayashi,
Tópico(s)Marine Toxins and Detection Methods
ResumoTwo new bromopyrrole alkaloids, nagelamides M (1) and N (2), have been isolated from an Okinawan marine sponge Agelas species, and the structures and stereochemistry were elucidated from the spectroscopic data. Nagelamide M (1) is a novel bromopyrrole alkaloid possessing a 2-amino-octahydropyrrolo[2,3-d]imidazole ring with a taurine unit, while nagelamide N (2) is a new bromopyrrole alkaloid possessing a 2-amino-tetrahydroimidazole-4-one ring with a taurine unit and 3-(dibromopyrrole-2-carboxamido)propanoic acid moiety. Nagelamides M (1) and N (2) exhibited antimicrobial activity.
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