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New perspectives on screening and early detection of endometrial cancer

2019; Wiley; Volume: 145; Issue: 12 Linguagem: Inglês

10.1002/ijc.32514

1097-0215

Laura Costas, Jon Frias‐Gomez, Magdalena Guardiola, Yolanda Benavente, Marta Pineda, Miguel Ángel Pavón, José Manuel Martínez, Maite Climent, Marc Barahona, Júlia Canet, Sònia Paytubi, Mònica Salinas, Luís Palomero, Ilaria Bianchi, Jaume Reventós, Gabriel Capellá, Mireia Díaz, August Vidal, Josep M. Piulats, Àlvaro Aytés, Jordi Ponce, Joan Brunet, F. Xavier Bosch, Xavier Matías‐Guiu, Laia Alemany, Sílvia de Sanjosé,

Cancer-related molecular mechanisms research

Due to the anatomical continuity of the uterine cavity with the cervix, genomic exploitation of material from routine Pap smears and other noninvasive sampling methods represent a unique opportunity to detect signs of disease using biological material shed from the upper genital tract. Recent research findings offer a promising perspective in the detection of endometrial cancer, but certain questions need to be addressed in order to accelerate the implementation of novel technologies in a routine screening or clinical setting. We discuss here new perspectives on detection of endometrial cancer using genomic and other biomarkers in minimally invasive sampling methods with a special focus on public health classic screening criteria, highlighting current gaps in knowledge.