Enantioselective Metal-catalyzed Baeyer-Villiger Oxidation of Cyclobutanones
1997; Thieme Medical Publishers (Germany); Volume: 1997; Issue: 10 Linguagem: Inglês
10.1055/s-1997-977
ISSN1437-2096
AutoresCarsten Bolm, T. Khanh Luong, Gunther Schlingloff,
Tópico(s)Oxidative Organic Chemistry Reactions
ResumoOptically active lactones are obtained by metal-catalyzed aerobic oxidation of prochiral cyclobutanones. Starting from 3-monosubstituted substrates lactones with moderate enantioselective (up to 47% ee) have been obtained. Kelly's tricyclic ketone 8 provides the corresponding lactone with 91% enantiomeric excess.
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