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Highly Enantioselective Phenyl Transfer to Aryl Aldehydes Catalyzed by Easily Accessible Chiral Tertiary Aminonaphthol

2005; American Chemical Society; Volume: 70; Issue: 3 Linguagem: Inglês

10.1021/jo048395i

1520-6904

Jian‐Xin Ji, Jing Wu, Terry T.‐L. Au‐Yeung, Chiu‐Wing Yip, Richard K. Haynes, Albert S. C. Chan,

Axial and Atropisomeric Chirality Synthesis

A new chiral tertiary aminonaphthol ligand 3b served as a highly efficient ligand for the asymmetric catalytic phenyl transfer to aromatic aldehydes and a variety of chiral diarylmethanols was prepared in high ee values (ee up to 99%) and chemical yields. The straightforward syntheses of both 3b and its enantiomer provide an excellent opportunity for large-scale applications.