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Microwave-Assisted Combinatorial Synthesis of Polysubstituent Imidazo[1,2- a ]quinoline, Pyrimido[1,2- a ]quinoline and Quinolino[1,2- a ]quinazoline Derivatives

2007; American Chemical Society; Volume: 9; Issue: 6 Linguagem: Inglês

10.1021/cc700124g

1520-4774

Shu‐Jiang Tu, Chunmei Li, Guigen Li, Longji Cao, Qingqing Shao, Dianxiang Zhou, Bo Jiang, Jian‐Feng Zhou, Min Xia,

Microwave-Assisted Synthesis and Applications

A series of unusual fused heterocyclic compound derivatives, consisting of a pyridine and a imidazole or pyrimidine core, with a bridgehead nitrogen, were successfully synthesized by a microwave-assisted, three-component domino reaction of aldehydes, enaminones, and malononnitrile. In this one-pot reaction, up to five new bonds were formed accompanied by generating the lactam group. This method has the advantages of short synthetic route, operational simplicity, increased safety for small-scale high-speed synthesis, and minimal environment impact.