A Convenient One-Pot Preparative Method for 4,5-Diarylisoxazoles Involving Amine Exchange Reactions
1996; American Chemical Society; Volume: 61; Issue: 16 Linguagem: Inglês
10.1021/jo960024h
ISSN1520-6904
AutoresEsther Domı́nguez, Estíbaliz Ibeas, Edorta Martínez de Marigorta, Jon Kepa Palacios, Raúl SanMartı́n,
Tópico(s)Synthesis and Catalytic Reactions
Resumo4,5-Diarylisoxazoles 1 are efficiently prepared by submitting enaminones 2, readily obtained from deoxybenzoins 3, to oximation conditions. This conversion implies an uncommon amine group exchange reaction. Preparation of 4-isoxazolines 5 and ring-opening transformations to β-keto nitriles 4 and 1,3-amino alcohol derivatives 7 are also described.
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