Solvent-free Synthesis of Thio-alkylxanthines from Alkylxanthines Using Microwave Irradiation
2000; Elsevier BV; Volume: 53; Issue: 10 Linguagem: Inglês
10.3987/com-00-9003
ISSN1881-0942
AutoresRodrigo Rico‐Gómez, Francisco Nájera, Juan Manuel López‐Romero, Pedro Cañada Rudner,
Tópico(s)Synthesis of heterocyclic compounds
ResumoAn expeditious, solvent-free procedure for the conversion of the xanthine bases theophylline, 8-methyltheophylline, caffeine, and theobromine to the corresponding 6-thio and 2,6-dithio derivatives using Lawesson's reagent under microwave irradiation is proposed.2][3][4] The usual approach involves the transformation of the 6-oxo group into its 6-thio
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