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Enantioselective routes toward 1β-methylcarbapenems from chiral aziridines

1992; Elsevier BV; Volume: 48; Issue: 29 Linguagem: Inglês

10.1016/s0040-4020(01)89856-2

1464-5416

David Tanner, Hua Ming He,

Synthesis of β-Lactam Compounds

This paper describes two enantioselective aziridine-based routes toward 1β-methylthienamycin, 2, and related carbapenems, the key steps being completely regioselective ring-opening reactions of the chiral aziridines 7 and 10 with AlMe3.