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Cytotoxic cycloartane-type triterpenes from Combretum quadrangulare

1998; Elsevier BV; Volume: 8; Issue: 24 Linguagem: Inglês

10.1016/s0960-894x(98)00644-1

1464-3405

Arjun H. Banskota, Yasuhiro Tezuka, Le Kim Phung, Kim Qui Tran, Ikuo Saiki, Yoshihisa Miwa, Tooru Taga, Shigetoshi Kadota,

Plant biochemistry and biosynthesis

Seven novel cycloartane-type triterpenes were isolated from Combretum quadrangulare, and their structures were elucidated on the basis of spectral analysis. All these compounds were tested for their cytotoxicity against murine colon 26-L5 carcinoma cells. Methyl quadrangularate B (2) and methyl quadrangularate D (4) exhibited potent cytotoxicity having ED50 values 9.54 and 5.42 μM, respectively.