Synthesis of 4-Quinolones through Nickel-Catalyzed Intramolecular Amination on the β-Carbon of o-(N-Alkylamino)propiophenones
2012; Thieme Medical Publishers (Germany); Volume: 23; Issue: 11 Linguagem: Inglês
10.1055/s-0031-1291146
ISSN1437-2096
AutoresSatoshi Ueno, Ryoichi Kuwano, Ryōsuke Shimizu, Ryohei Maeda,
Tópico(s)Asymmetric Synthesis and Catalysis
Resumoo -( N -Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o -( N -alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.
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