Pd-Catalyzed Cross-Coupling Reaction of Alkyl Tosylates and Bromides with Grignard Reagents in the Presence of 1,3-Butadiene
2003; Oxford University Press; Volume: 32; Issue: 10 Linguagem: Inglês
10.1246/cl.2003.890
ISSN1348-0715
AutoresJun Terao, Yoshitaka Naitoh, Hitoshi Kuniyasu, Nobuaki Kambe,
Tópico(s)Catalytic Alkyne Reactions
ResumoAbstract A new method for cross-coupling reaction of alkyl tosylates and bromides with Grignard reagents has been developed by the use of Pd(acac)2 or PdCl2 as the catalyst. Addition of 1,3-butadiene is essential to afford good yields of coupling products. This reaction proceeds efficiently at room temperature using primary and secondary alkyl and aryl Grignard reagents.
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