A facile microwave-assisted palladium-catalyzed cyanation of aryl chlorides
2006; Elsevier BV; Volume: 47; Issue: 19 Linguagem: Inglês
10.1016/j.tetlet.2006.03.026
ISSN1873-3581
AutoresHarry R. Chobanian, Brett P. Fors, Linus S. Lin,
Tópico(s)Sulfur-Based Synthesis Techniques
ResumoWe report an efficient method for the preparation of aryl nitriles from aryl chlorides under either microwave assisted or thermal conditions. A catalyst system comprising tris(dibenzylidene acetone)dipalladium (Pd2(dba)3) and 2-(2′,6′-dimethoxybiphenyl)dicyclohexylphosphine (S-Phos) is shown to effectively promote cyanation of various aryl chlorides with Zn(CN)2 as the cyanide source.
Referência(s)