PhI(OAc)2 induced intramolecular oxidative bromocyclization of homoallylic sulfonamides with KBr as the bromine source
2007; Elsevier BV; Volume: 48; Issue: 42 Linguagem: Inglês
10.1016/j.tetlet.2007.08.085
ISSN1873-3581
AutoresRenhua Fan, Fengqi Wen, Luoheng Qin, Dongming Pu, Bing Wang,
Tópico(s)Synthesis and Catalytic Reactions
Resumo(Diacetoxyiodo)benzene (PhI(OAc)2) was found to be a powerful reagent to induce the intramolecular oxidative bromocyclization of homoallylic sulfonamides utilizing KBr as the bromine source. The reaction affords 2-substituted-4-bromo-pyrrolidines in moderate to excellent yields under a mild metal-free condition, and offers good manipulability by avoiding the use of highly toxic and caustic bromine (Br2).
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