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Diterpenes from Sideritis infernalis and S. candicans

2008; De Gruyter; Volume: 63; Issue: 5 Linguagem: Inglês

10.1515/znb-2008-0519

1865-7117

Braulio M. Fraga, Carlo Bressa, Concepción Fernández, Pedro González, Ricardo Guillermo, Melchor G. Hernández,

Phytochemistry and Bioactive Compounds

A phytochemical study of Sideritis infernalis led to the isolation of the new nor-diterpene adejone (17-nor-7α,18-dihydroxy-ent-kaur-16-one). The biosynthesis of this compound implies the decarboxylation of an epoxy-acid as the last step. In addition, three diterpenes with an ent-kaurene skeleton, episideridiol, candicandiol 7α-monoacetate and candidiol 15α-monoacetate, have been isolated from S. candicans for the first time in nature.