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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom

2003; Elsevier BV; Volume: 14; Issue: 2 Linguagem: Inglês

10.1016/j.bmcl.2003.10.044

ISSN

1464-3405

Autores

Alcides J. M. da Silva, Antonio L. Coelho, Alessandro B. C. Simas, Raphael A.M. Moraes, Diogo A. Pinheiro, Fabrício Freitas Fernandes, Emerson Z. Arruda, Paulo R. R. Costa, Paulo A. Melo,

Tópico(s)

Synthesis and bioactivity of alkaloids

Resumo

Edunol (3), a pterocarpan isolated from Harpalyce brasiliana, a plant used in the northeast of Brazil against snakebites, was obtained by synthesis and showed antimyotoxic, antiproteolytic and PLA2 inhibitor properties. These proprieties could be improved through the synthesis of a bioisoster (5), where the prenyl group was replaced by the benzyl group.

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