Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK-912: an O-analogue of the Pictet-Spengler reaction
1999; Elsevier BV; Volume: 40; Issue: 27 Linguagem: Inglês
10.1016/s0040-4039(99)00840-0
ISSN1873-3581
AutoresJennifer Albaneze‐Walker, Kai Rossen, Robert A. Reamer, R. P. Volante, Paul J. Reider,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoEfficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet-Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.
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